A research study at Brigham and Women's Hospital is looking to see if "Circadin", a medication with melatonin, will improve how the pancreas, kidney and blood vessels work. Melatonin is a hormone that is naturally produced by your body at night before you go to sleep.
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You may be eligible if you are:
-18 years or older
- Obese (BMI>30)
If you choose to participate, you will be randomly assigned to take melatonin or placebo (contains no active drug) for 12 weeks.
In this study, you will be asked to attend the following at Brigham and Women's Hospital:
1 -- 60 minute screening visit
2 -- 48 hour overnight inpatient hospital stays that are 12 weeks apart
1 -- 30 minute check up visit
We will also ask you to wear a wrist actigraph (like a fitbit) for a total of 14 days and a blood pressure monitor for 1 day.
Those that complete the study will receive $975.